Exploring the nucleotide regulatory sites using a combination of computational and experimental approaches helps understand the allosteric regulation of higher eukaryotic GDHs


Understanding sidechain Networks and Allostery

Using homology models of early to higher eukaryotes we can identify potential networks of side chains that empower allosteric interactions- these are now being explored using limited proteolysis and tandem mass spectrometry 



The Architecture of Glutamate Dehydrogenase




Coordinated Motions may control allostery 

We are exploring the novel concept that an "entropy sink" may be involved in powering allosteric interactions triggered by a variety of allosteric effectors