Welcom to the Bell Lab Journal Club and Resources
The Journal club is held in conjunction with the Malate Dehydrogenase CUREs Community and discusses seminal papers on a variety of topics related to Malate Dehydrogenase Structure-Function relationships.
All interested scientists are invited to participate in addition to Bell Lab members. Zoom links for the various sessions are provided below.
Each session is recorded and the recording and ancilliary materials made available via the topic links below.
Topic: The Bell Lab MCC Journal Club-MOLECULAR Life Sciences' Zoom Meeting
Time: Oct 12, 2023 05:00 PM Pacific Time (US and Canada)
Every month on the Second Thu, 10 occurrence(s)
Please download and import the following iCalendar (.ics) files to your calendar system.
Monthly: https://us02web.zoom.us/meeting/tZAkc-iorT8rG9Gzzn93-9vruHh-rWskcy6V/ics?icsToken=98tyKuGspz8rGteRsRiCRpwIHY-gd_Tztilcjfp6hgXrWnMeOxXkI8pKf6BIA9PT
Join Zoom Meeting
https://us02web.zoom.us/j/84941034115?pwd=dGV3NHhTWXFKYmw0dGxSSnpjN09TUT09
Meeting ID: 849 4103 4115
Passcode: 754599
Mechanism of Catalysis,
Primary Paper: J Biol Chem, 258, No. 1, Issue of January IO, pp. 472-482: https://pubmed.ncbi.nlm.nih.gov/6848515/
The Presence of a Histidine-Aspartic Acid Pair in the Active Site of
2-Hydroxyacid Dehydrogenases
Secondary Papers:
https://pubmed.ncbi.nlm.nih.gov/31361/
https://pubmed.ncbi.nlm.nih.gov/9125501/
https://pubmed.ncbi.nlm.nih.gov/8665917/
https://pubmed.ncbi.nlm.nih.gov/6959107/
Kinetic Mechanism,
Primary Paper: J Biol Chem, 1968 May 10;243(9):2413-23: https://pubmed.ncbi.nlm.nih.gov/4296842/
Kinetic Studies on the Mechanism of the Malate Dehydrogenase Reaction
Secondary Papers:
https://pubmed.ncbi.nlm.nih.gov/25606688/
https://pubmed.ncbi.nlm.nih.gov/4307999/
THURSDAY DECEMBER 14TH
Metabolon Formation
Primary Paper: Angew Chem Int Ed Engl. 2015 Feb 2;54(6):1851-4. doi: 10.1002/anie.201409336. Epub 2014 Dec 23. PMID: 25537779.: https://pubmed.ncbi.nlm.nih.gov/25537779/
Krebs Cycle Metabolon: Structural Evidence of Substrate Channeling
Revealed by Cross-Linking and Mass Spectrometry**
Secondary Papers:
https://pubmed.ncbi.nlm.nih.gov/27556423/
https://pubmed.ncbi.nlm.nih.gov/8611153/
https://pubmed.ncbi.nlm.nih.gov/37102132/
https://pubmed.ncbi.nlm.nih.gov/34548590/
https://pubmed.ncbi.nlm.nih.gov/29094409/
https://pubmed.ncbi.nlm.nih.gov/24325460/
THURSDAY JANUARY 11TH
Cofactor Specificity,
Primary Paper: J Biol Chem. 1993 Mar 5;268(7):4656-60. PMID: 8444839.
https://pubmed.ncbi.nlm.nih.gov/8444839/
Alteration of coenzyme specificity of malate dehydrogenase from Thermus flavus by site-directed mutagenesis.
Secondary Papers:
https://pubmed.ncbi.nlm.nih.gov/7832772/
https://pubmed.ncbi.nlm.nih.gov/30638660/
https://pubmed.ncbi.nlm.nih.gov/19772885/
https://pubmed.ncbi.nlm.nih.gov/7833810/
THURSDAY FEBRUARY 8TH
Oligomeric Structure,
Primary Paper: Protein Sci. 1994 Nov;3(11):2023-32. doi: 10.1002/pro.5560031115. PMID: 7703849; PMCID: PMC2142640.: https://pubmed.ncbi.nlm.nih.gov/7703849/
Engineering the quaternary structure of an enzyme: construction and analysis of a monomeric form of malate dehydrogenase from Escherichia coli.
Secondary Papers
https://pubmed.ncbi.nlm.nih.gov/3114237/
https://pubmed.ncbi.nlm.nih.gov/31301348/
https://pubmed.ncbi.nlm.nih.gov/10825536/
THURSDAY MARCH 14TH
Interface and Allostery,
Primary: J Biol Chem. 1982 Nov 25;257(22):13233-9. PMID: 7142142.: https://pubmed.ncbi.nlm.nih.gov/7142142/
Regulation of mitochondrial malate dehydrogenase. Evidence for an allosteric citrate-binding site.
Secondary:
https://pubmed.ncbi.nlm.nih.gov/8251495/
https://pubmed.ncbi.nlm.nih.gov/4299102/
https://pubmed.ncbi.nlm.nih.gov/3985618/
THURSDAY APRIL 11TH
MDH and Drug Design,
Primary Paper: Commun Biol. 2021 Aug 10;4(1):949. doi: 10.1038/s42003-021-02442-1. PMID: 34376783; PMCID: PMC8355244.: https://pubmed.ncbi.nlm.nih.gov/34376783/
A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity
Secondary Papers
https://pubmed.ncbi.nlm.nih.gov/29694407/
https://pubmed.ncbi.nlm.nih.gov/8615849/
https://pubmed.ncbi.nlm.nih.gov/30108105/
THURSDAY MAY 9TH
Loop and Substrate Specificity,
Primary Paper: Nat Chem Biol. 2017 May;13(5):494-500. doi: 10.1038/nchembio.2307. Epub 2017 Mar 6. PMID: 28263965; PMCID: PMC5516644.: https://pubmed.ncbi.nlm.nih.gov/28263965/
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
Secondary Papers
https://pubmed.ncbi.nlm.nih.gov/10075524/
https://pubmed.ncbi.nlm.nih.gov/27510037/
https://pubmed.ncbi.nlm.nih.gov/7574693/
https://pubmed.ncbi.nlm.nih.gov/34850194/
THURSDAY JUNE 13TH
PTMs and MDH
Primary Paper: Plant J. 2022 Jan;109(1):92-111. doi: 10.1111/tpj.15556. Epub 2021 Nov 10. PMID: 34713507.: https://pubmed.ncbi.nlm.nih.gov/34713507/
Acetylation of conserved lysines fine-tunes mitochondrial malate dehydrogenase activity in land plants
Secondary Papers
https://pubmed.ncbi.nlm.nih.gov/7986072/
https://pubmed.ncbi.nlm.nih.gov/28366830/
https://pubmed.ncbi.nlm.nih.gov/35879546/